10. St. Louis, Missouri
St. Louis is a major US port in eastern Missouri. The city, whose population is estimated to be around 320,000, is the second largest in the state. Almost 15% of St. Louis’ population is living below the poverty line. Missouri was one of only two states in the country to experience a fall in annual household income last year. The crime rate in St. Louis is also very high, making it one of the worst places to live in the US, especially for families. The murder rate in St. Louis is reported to be 35.3 per 100,000 residents, which ranks it as one of America’s most dangerous cities too.